Barbara Hoffmann

Barbara Hoffmann PD Dr. med. MPH

Tel.: +49 201 / 723 4463
Fax.: +49 201 / 723 5933

barbara.hoffmann@uk-essen.de
   
 

Curriculum vitae
 

Beruflicher und wissenschaftlicher Werdegang
seit 2005 Leiterin der Arbeitsgruppe Unweltepidemiologie und Klinische Epidemiologie;
Institut für Medizinische Informatik, Biometrie und Epidemiologie
Universität Duisburg-Essen
2006-2008 Kommissarische Leiterin der Arbeitsgruppe Biometrie und Bioinformatik;
Institut für Medizinische Informatik, Biometrie und Epidemiologie
Universität Duisburg-Essen
2001 – 2004 Wissenschaftliche Mitarbeiterin;
Institut für Medizinische Informatik, Biometrie und Epidemiologie
Universität Duisburg-Essen
1999-2000 Ärztliche Beraterin für Versorgungsmanagement;
BKK für Heilberufe, Düsseldorf
1995-1996 Assistenzärztin;
Klinik für Innere Medizin, St. Clemens Hospital, Geldern
1994-1995 Assistenzärztin;
Klinik für Lungen- und Bronchialheilkunde, Ev. und Johanniter Krankenanstalten Duisburg und Oberhausen
1993-1994 Ärztin im Praktikum;
Klinik für Lungen- und Bronchialheilkunde, Ev. und Johanniter Krankenanstalten Duisburg und Oberhausen
1989-1990 Predoctoral Fellowship
Pulmonary Department, LDS Hospital
University of Utah

Ausbildung
1999 M.P.H., Universität Bielefeld;
Fakultät für Gesundheitswissenschaften
Diplomarbeit: Geschlechtsspezifische Unterschiede bei Infektionskrankheiten
1996 Dr. med., RWTH Aachen;
Medizinische Fakultät
Dissertation: Arterieller PCO2 während extrakorporaler CO2 Elimination und Low Frequency Positive Pressure Ventilation (LFPPV-ECCO2R) in Patienten mit Adult Respiratory Distress Syndrome (ARDS) - Haldane Effekt und Lungenmetabolismus
1993 Ärztliche Prüfung, RWTH Aachen;
Medizinische Fakultät
1992 Amerikanische Ärztliche Prüfung für Nichtamerikaner;
Educational Commission for Foreign Medical Graduates (ECFMG)-Certification

 

Forschungsschwerpunkte/Projekte

My current research focus is the investigation of human health effects from exposure to environmental hazards. One major research project is the investigation of short- and long-term cardiovascular health effects of air pollution within the framework of the Heinz Nixdorf Recall Study. Major results include the association of long-term residential traffic exposure with the prevalence of coronary heart disease and the degree of coronary calcification, pointing to atherogenesis as a possible important mechanism of PM action on cardiovascular health. Research activities encompassing the development of the exposure assessment (historical exposures, traffic exposure by vehicle type, personal exposure modelling) and the investigation of possible mechanisms of cardiovascular health effects like the induction of hypertension and inflammation are currently under way.
For the investigation of short-term effects of particulate matter on the triggering of acute coronary events, we are linking data from the myocardial infarction registry in Essen, a clinic based registry for acute ST-elevation myocardial infarctions, to the hourly air pollution concentrations, using a case-crossover design.
A further environmental health project encompasses the investigation of the cause-specific mortality in Essen during the 2003 and 2006 heat waves in Germany.

I am also engaged in several projects in the area of general and clinical epidemiology. Currently I am leading the quality assurance measures and biometrical evaluation of a population-based follow-up study funded by the German Phlebologic Society on the incidence of phlebological diseases and their risk factors.
A further epidemiological project consists of the evaluation of the newly installed population-wide mammography screening for breast cancer. The purpose of this study is to investigate aspects of feasibility and effectiveness of the screening program in the field phase.
Finally, I am currently participating in a number of projects and proposals led by my clinical colleagues at the University Hospital of Essen, such as the investigation of the role of thyroid gland function on the success of artificial reproduction, the evaluation of chronic psychosocial stress on the time until pregnancy in women desiring to start a family, and the role of early surgical interventions in the inflammatory reaction after multiple trauma.

Publikationen

Reimann V, Krämer U, Sugiri D, Schroeder P, Hoffmann B, Medve-Königs K, Jöckel KH, Ranft U, and Krutmann J. Sunbed use induces the photoaging-associated mitochondrial common deletion. J Invest Dermatol 2007. epub Nov 8, 2007. http://www.nature.com/doifinder/5701151


Hoffmann B, Moebus S, Möhlenkamp S, Stang A, Lehmann N, Dragano N, Schmermund A, Memmesheimer M, Mann K, Erbel R and Jöckel KH. Residential exposure to traffic is associated with coronary atherosclerosis. Circulation 2007;116:489-496.


Möhlenkamp S, Moebus S, Schmermund A, Lehmann N, Hoffmann B, Neumann T, Stang A, Dragano N, Kerkhoff G, Naber C, Kalsch H, Beck EM, Brocker-Preuss M, Kroger K, Budde T, Siegrist J, Mann K, Jockel KH, Erbel R; für die Studiengruppe der Heinz Nixdorf Recall Studie. Assessment of the natural history of coronary artery calcification and identification of its determinants. Rationale of the 2nd part of the Heinz Nixdorf Recall Study. Herz. 2007 Mar;32(2):108-20.


Hellmeier W, Stausberg J, Hoffmann B. Untersuchungen in NRW zu Auswirkungen der Hitzewelle 2003 auf die kurzzeitige Mortalität. 2007. Bielefeld, Münster, lögd. Materialien "Umwelt und Gesundheit".


Hoffmann B, Straif K, Wichmann HE, Jöckel KH. Staub- und Staubinhaltsstoffe/Passivrauchen. In: Handbuch der Umweltmedizin, Hrsg. Wichmann, Schlipköter, Fülgraff. Ecomed Landsberg/Lech, 2006.


Hoffmann B, Moebus S, Stang A, Beck EM, Dragano N, Möhlenkamp S, Schmermund A, Memmesheimer M, Mann K, Erbel R, Jöckel KH. Residence close to high traffic and prevalence of coronary heart disease. Eur Heart J 2006;27(22):2696-2702.


Hoffmann B and Jöckel KH. Diesel-Exhaust and Coal Mine dust – Lung Cancer Risk in Occupational Settings -. Ann NY Acad Sci 2006;1076:253-265.


Hoffmann B, Straif K, Wichmann H-E, Jöckel K-H. Gesundheitliche Folgen des Passivrauchens. Umweltmedizin in Forschung und Praxis 2006; 11 (6), 369-385


Hauth EAM, Hoffmann B, Jäger H, Jöckel KH, Forsting M. Epidemiologische und kernspintomographische Verlaufskontrolle 10 Jahre nach vermutlich falscher Diagnose Brustkrebs. Senologie 2006; 3:128-135.


Michalsen A, Hoffmann B, Moebus S, Backer M, Langhorst J, Dobos GJ. Incorporation of fasting therapy in an integrative medicine ward: evaluation of outcome, safety, and effects on lifestyle adherence in a large prospective cohort study. J Altern Complement Med 2005;11(4):601-607.


Hoffmann B, Moebus S, Michalsen A, Paul A, Spahn G, Dobos GJ, Jöckel KH. Gesundheitsbezogene Kontrollüberzeugung und Lebensqualität bei chronisch Kranken nach stationärer Behandlung mit Integrativer Medizin – eine Beobachtungsstudie. Forsch Komplementärmed Klass Naturheilk 2004;11:159-170.


Laaser U, Breckenkamp J, Ullrich A, Hoffmann B. Can a decline in the population means of cardiovascular risk factors reduce the number of people at risk? J Epidemiol Community Health 2001;55:179-184.


Morris AH, Wallace CJ, Menlove RL, Clemmer TP, Orme JF, Weaver LK, Dean NC, Thomas F, East TD, Pace NL, Suchyta MR, Beck E, Bombino M, Sittig DF, Böhm S, Hoffmann B, Becks H, Butler S, Pearl J, Rasmussen B. Randomized Clinical-Trial of Pressure-Controlled Inverse Ratio Ventilation and Extracorporeal CO2 Removal for Adult Respiratory Distress Syndrome. Am J Respir Crit Care Med 1994;149(2):295-305.


Hoffmann BH, Böhm SH, Morris AH, Simon B, Mottaghy K. In vivo demonstration of the Haldane effect during extracorporeal gas exchange. The International Journal of Artificial Organs 1991;14 (11):703-706 .

Vorträge

Hoffmann B. Atherosclerotic Effects of Chronic Particulate Air Pollution: The Heinz Nixdorf Recall Study. Seminar. Harvard School of Public Health, Boston 2007.


Hoffmann B, Kolahgar B, Rauchfuss, K, Eberwein G, Franzen-Reuter I, Kraft M, Wilhelm M, Ranft U, Jöckel KH. Childhood social position and associations between environmental exposures and health outcomes. 52nd annual conference Deutsche Gesellschaft für medizinische Informatik, Biometrie und Epidemiologie and 2nd annual conference Deutsche Gesellschaft für Epidemiologie "Medizin und Gesellschaft", Augsburg 2007.


Hoffmann B. Air pollution and atherosclerosis in humans – the slim state of epidemiological evidence. Annual Conference of the International society for Environmental Epidemiology, Mexico City 2007.


Hoffmann B, Moebus S, Stang A, Erbel R, Jöckel KH. Long-term residential exposure to urban air pollution and inflammatory markers. Annual Conference of the International society for Environmental Epidemiology, Mexico City 2007.


Hoffmann B, Moebus S, Kröger K, Stang A, Erbel R, Jöckel KH. Long-term residential exposure to traffic and peripheral arterial disease in the Heinz Nixdorf Recall Study. Annual Conference of the International society for Environmental Epidemiology, Mexico City 2007.


Hoffmann B, Kolahgar B, Rauchfuss, K, Eberwein G, Franzen-Reuter I, Kraft M, Wilhelm M, Ranft U, Jöckel KH. Childhood social position and associations between environmental exposures and health outcomes. Environmental Toxicology in North Rhine-Westphalia, Germany – Interdisciplinary Research Activities in Toxicology, Statistics, Hygiene and Medicine. Dortmund 2007.


Hoffmann B, Moebus S, Stang A, Lehmann N, Erbel R, Jöckel KH. Long-term personal exposure to traffic and coronary calcification. 51st annual conference Deutsche Gesellschaft für medizinische Informatik, Biometrie und Epidemiologie. Leipzig 2006.


Hoffmann B, Moebus S, Stang A, Lehmann N, Erbel R, Jöckel KH. Long-term personal exposure to traffic and coronary calcification. 10th International Inhalation Symposium, Hannover 2006.


Hoffmann B, Jöckel KH. Lung Cancer risk of occupational exposure to diesel exhaust and coal mine dust. Collegium Ramazini: 3rd International Scientific Conference. Framing the future in the light of the past: Living in a chemical world. Bologna 2005.


Hoffmann B, Jöckel KH. Passivrauchen aus epidemiologischer Sicht. 8. Deutsche Nikotinkonferenz. Erfurt 2005.


Lehrveranstaltungen

Epidemiologie, Medizinische Biometrie und Medizinische Informatik

Arbeits- und Umweltmedizin

Methodik wissenschaftlichen Arbeitens

Klinische Epidemiologie