Sonali Pechlivanis

Bitte angeben... Dr. sc. hum.

Tel.: +49 201 / 92239 213
Fax: +49 201 / 92239 333

sonali.pechlivanis[at]uk-essen.de
   
 

Curriculum vitae

 

Beruflicher und wissenschaftlicher Werdegang

seit 06/2008 wissenschaftliche Mitarbeiterin am Institut für Medizinische Informatik, Biometrie und Epidemiologie, Universitätsklinikum Essen
09/2004 – 09/2007 Promotion an der Medizinischen Fakultät der Ruprecht-Karls Universität Heidelberg, Dr. sc. hum., Thema: Low-penetrance susceptibility genes for colorectal cancer in the insulin/insulin like growth factor 1 axis
09/2002 – 07/2004 Master of Science (MSc) in Biomedical Engineering, FH Aachen, Germany
06/1997 - 06/2000 Bachelors in Biomedical Engineering, M.G.M.C.E.T. Mumbai University, India

 

Forschungsschwerpunkte

  • Genetische Epidemiologie
  • Genomweite Assoziationsstudien
  • Pharmakogenetik

Projekte

Genetische Epidemiologie
 
 
  • „Genetische Determinanten der Progression der koronaren Gefäß Verkalkung in der Heinz Nixdorf Recall Studie: Eine Genomweite Assoziation Studie“ von der DFG finanziert
  • Untersuchen die Assoziationen zwischen der androgenetischen Alopezie mit koronarer Herzkrankheit (KHK) und KHK assoziiert Phänotypen sowohl auf epidemiologischer als auch auf molekulargenetischer Ebene.
  • Zusammenarbeit mit mehreren Konsortien (DIAGRAM, GIANT, CHARGE) zu verschiedenen Themen

Phenome Wide Association Studies
 
 
  • Explorative Analyse von LPS-induzierten e-QTL-SNPs mit HNR-Daten – Eine Phänotypweite Assoziation Studie (Bachelorarbeit)

Pharmakoepidemiologie
 
 
  • Pharmakogenetische Assoziation von Lipiden Assoziierte genetischen Varianten mit Progression der Kalzifikation der Koronararterien nach Statinbehandlung.
  • Einfluss von Statinmedikation und genetischem Risiko auf die Entwicklung von Typ-2 Diabetes (Bachelorarbeit)
  • Wirkung von Antihypertensiva auf Inzidenzdiabetes (Doktorarbeit)
  • Einfluss von Antidiabetika auf ein Mild-Cognitive-Impairment (Bachelorarbeit)

Publikationen

Scott RA, Scott LJ, …, Pechlivanis S, .. et al. An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes. 2017 Nov;66(11):2888-2902.

Schmidt B, Frölich S, …, Pechlivanis S, et al. Socioeconomic Status Interacts with the Genetic Effect of a Chromosome 9p21.3 Common Variant to Influence Coronary Artery Calcification and Incident Coronary Events in the Heinz Nixdorf Recall Study (Risk Factors, Evaluation of Coronary Calcium, and Lifestyle). Circ Cardiovasc Genet. 2017 Apr;10(2).

Heilmann-Heimbach S, Herold C, …., Pechlivanis S, et al. Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nat Commun. 2017 Mar 8;8:14694. doi: 10.1038/ncomms14694.

Weinhold L, Wahl S, Pechlivanis S, Hoffmann P, Schmid M. A statistical model for the analysis of beta values in DNA methylation studies. BMC Bioinformatics. 2016 Nov 22;17(1):480.

Hartwig S, Kluttig A, Tiller D, Fricke J, Müller G, Schipf S, Völzke H, Schunk M, Meisinger C, Schienkiewitz A, Heidemann C, Moebus S, Pechlivanis S, Werdan K, Kuss O, Tamayo T, Haerting J, Greiser KH.Anthropometric markers and their association with incident type 2 diabetes mellitus: which marker is best for prediction? Pooled analysis of four German population-based cohort studies and comparison with a nationwide cohort study. BMJ Open. 2016 Jan 20;6(1):e009266. doi: 10.1136/bmjopen-2015-009266.

Gaulton KJ, Ferreira T, …., Pechlivanis S, et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet. 2015 Dec;47(12):1415-25. doi: 10.1038/ng.3437.

Locke AE, Kahali B, Berndt SI,…, Pechlivanis S, ... et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206.

Shungin D, Winkler TW, Croteau-Chonka DC,.., Pechlivanis S, …et al.New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015 Feb 12;518(7538):187-96.

van Setten J, Išgum I, Pechlivanis S, et al. Serum Lipid Levels, Body Mass Index, and Their Role in Coronary Artery Calcification: A Polygenic Analysis. Circ Cardiovasc Genet. 2015 Jan 10

Wood AR, Esko T, Yang J,…, Pechlivanis S,… et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet. 2014 Nov;46(11):1173-86.

Hoggart CJ, Venturini G, Mangino M, …, Pechlivanis S, … et al. Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. PLoS Genet. 2014 Jul 31;10(7):e1004508.

Schmidt B, Dragano N, Scherag A, Pechlivanis S, et al. Exploring genetic variants predisposing to diabetes mellitus and their association with indicators of socioeconomic status. BMC Public Health. 2014 Jun 16;14:609.

Winkler TW, Day FR, Croteau-Chonka DC, …, Pechlivanis S,… et al. Quality control and conduct of genome-wide association meta-analyses. Nat Protoc. 2014 May;9(5):1192-212.

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, … Pechlivanis S,….. et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar;46(3):234-44.

Tan S, Dieterle S, Pechlivanis S, et al. Thyroid autoantibodies per se do not impair intracytoplasmic sperm injection outcome in euthyroid healthy women. Eur J Endocrinol. 2014 Mar 8;170(4):495-500.

Hu YJ, Berndt SI, Gustafsson S, Ganna A, …., Pechlivanis S, … et al. Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. Am J Hum Genet. 2013 Jul 24; pii: S0002-9297(13)00280-2.

Randall JC, Winkler TW, Kutalik Z,…., Pechlivanis S, … et al. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genet. 2013 Jun;9(6):e1003500.

Schimmelmann BG1, Hinney A, Scherag A, Pütter C, Pechlivanis S, … et al. Bipolar disorder risk alleles in children with ADHD. Journal of Neural transmission 2013 May 28.

Berndt SI, Gustafsson S, Mägi R,…., Pechlivanis S, … et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetic 2013 April 26; 45 (5):501-12.

Pechlivanis S, Mühleisen TW, Möhlenkamp S, et al. Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study. BMC Medical Genetic 2013 Februar 8;14:23.

Thanassoulis G, Campbell CY, Owens DS,…., Pechlivanis S, … et al. Genetic associations with valvular calcification and aortic stenosis. New England Journal of Medicine 2013 Februar 7;368(6):503-12.

di Giuseppe R, Pechlivanis S, Fisher E, et al. Microsomal triglyceride transfer protein -164 T > C gene polymorphism and risk of cardiovascular disease: results from the EPIC-Potsdam case-cohort study. BMC Medical Genetics 2013 Januar 29; 14:19.

Icks A, Albers B, Haastert B, Pechlivanis S, .. et al. Diabetes incidence does not differ between subjects with and without high depressive symptoms--5-year follow-up results of the Heinz Nixdorf Recall Study. Diabetic Medicine 2013 Januar;30(1):65-9.

Icks A, Albers B, Haastert B, Pechlivanis S, et al. Risk for high depressive symptoms in diagnosed and previously undetected diabetes: 5-year follow-up results of the Heinz Nixdorf Recall study. PLoS One 2013;8(2):e56300.

Jarick I, Volckmar AL, Pütter C, Pechlivanis S,.. et al. Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder. Molecular Psychiatry 2012 November 20 doi: 10.1038/mp.2012.161.

Morris AP, Voight BF, Teslovich TM,…., Pechlivanis S, … et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics 2012 September; 44(9):981-90.

Schimming TT, Grabellus F, Roner M, Pechlivanis S, et al. PHH3 immunostaining improves interobserver agreement of mitotic index in thin melanomas. The American Journal of Dermatopathology.

Heinemann A, Zhao F, Pechlivanis S, … et al. Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D. Cancer Research 2012 Januar 15;72(2):460-71.

Hinney A, Scherag A, Jarick I,…., Pechlivanis S, … et al. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics B Neuropsychiatric Genetics 2011 Dezember;156B(8):888-97.

Pütter C, Pechlivanis S, Nöthen MM, et al. Missing heritability in the tails of quantitative traits? A simulation study on the impact of slightly altered true genetic models. Human Heredity 2011;72(3):173-81.

Pechlivanis S, Scherag A, Mühleisen TW, et al. Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010 Sep;30(9):1867-72.

Pechlivanis S, Bermejo JL, Pardini B, et al. Genetic variation in adipokine genes and risk of colorectal cancer. European Journal of Endocrinology 2009 Jun;160(6):933-40.

Pechlivanis S, Wagner K, Chang-Claude J, et al. Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer. Cancer Detection and Prevention 2007;31(5):408-16.

Pechlivanis S, Pardini B, Bermejo JL, et al. Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect. Endocrine-Related Cancer. 2007 Sep;14(3):733-40.

Buchkapitel

Metabochip – a next generation genotyping platform. Biometrische Aspekte der Genomanalyse IV: Next Generation Sequencing Data Analysis; ISBN-13: 978-844001556; 47-54.

Lehrveranstaltungen

  • Querschnitt Epidemiologie, med. Biometrie, med. Informatik, Teil 2
  • Methodik wissenschaftlichen Arbeitens